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INF 4E

Cat. No. 6172 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Caspase-1 and NLRP3 inflammasome inhibitor
化学名： Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
文献 (5)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for INF 4E

INF 4E is a NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 μM for caspase-1). Inhibits Nigericin (Cat. No. 4312) or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.

技术数据 for INF 4E

分子量 240.68
公式 C12H13ClO3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 88039-46-7
PubChem ID 11402215
InChI Key BSRPDXCMAOIUOO-UHFFFAOYSA-N
Smiles CCOC(C(C(C1=C(C=CC=C1)Cl)O)=C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for INF 4E

溶解性 Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

参考文献 for INF 4E

参考文献是支持产品生物活性的出版物。

Cocco et al (2014) Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J.Med.Chem. 57 10366 PMID: 25418070

If you know of a relevant reference for INF 4E, please let us know.

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关键词: INF 4E, INF 4E supplier, INF4E, NLRP3, inflammasomes, caspases, 1, inhibitors, inhibits, pyroptosis, nrf2, Caspases, Inflammasomes, Nrf2, 6172, Tocris Bioscience

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The inhibitor can inhibit NLRP3 inflammasomes and block IL-1b production.
By Xiaogang Wang on 09/15/2020
分析类型： In Vitro
种属： Human
细胞系/组织： THP-1

We used this product to study whether bacterial component can induce NLRP3-mediated IL-1beta production. To confirm whether this inhibitor works well, we pretreated THP-1 cells with the inhibitor for 1 h, followed by treatment with LPS+ATP for 2 h. The production of IL-1b in culture supernatant was measured by IL-1b ELISA kit. We showed that this inhibitor can significantly inhibit LPS/ATP-induced IL-1b production.

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