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Ionomycin free acid

Cat. No. 2092 1 次引用 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Calcium ionophore
化学名： (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid
纯度： ≥95% (HPLC)
说明书
引用文献 (1)
评论 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ionomycin free acid

Ionomycin free acid is a calcium ionophore; more specific than A23187.

Calcium Salt also available.

技术数据 for Ionomycin free acid

分子量 709.01
公式 C41H72O9
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 56092-81-0
PubChem ID 6912226
InChI Key PGHMRUGBZOYCAA-ADZNBVRBSA-N
Smiles O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@@H](C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@]2([H])O[C@@]([C@H](O)C)(C)CC2)(C)O1)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ionomycin free acid

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.09 10

制备储备液 for Ionomycin free acid

以下数据基于产品分子量 709.01。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 14.1 mL 70.52 mL 141.04 mL
0.5 mM 2.82 mL 14.1 mL 28.21 mL
1 mM 1.41 mL 7.05 mL 14.1 mL
5 mM 0.28 mL 1.41 mL 2.82 mL

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产品说明书 for Ionomycin free acid

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Ionomycin free acid

参考文献是支持产品生物活性的出版物。

Liu and Hermann (1978) Characterization of ionomycin as a calcium ionophore. J.Biol.Chem. 253 5892 PMID: 28319

Kaufmann et al (1980) Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J.Biol.Chem. 255 2735 PMID: 6766939

Elzi et al (2001) Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. Am.J.Physiol.Cell Physiol. 281 C350 PMID: 11401859

If you know of a relevant reference for Ionomycin free acid, please let us know.

按标靶查看相关产品

关键词: Ionomycin free acid, Ionomycin free acid supplier, Calcium, ionophore, Signaling, Signalling, Agents, General, Ca2+, Ionophore, Ionophores, Antibiotics, 2092, Tocris Bioscience

1 篇 Ionomycin free acid 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ionomycin free acid 的部分引用包括：

Mestre et al (2019) Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis. Front Immunol 10 1374 PMID: 31258540

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Ionomycin free acid 的评论

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Ionomycin releases Ca2+ from intracellular stores..
By Anonymous on 01/02/2020
分析类型： In Vitro
种属： Human
细胞系/组织： HEK293

HEK293 cells were loaded with 1 µM intracellular Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 30 min in dark, washed, and left to equilibrate for 15 min. Fura2-loaded cells were excited alternately at 340 and 380 nm and the fluorescence at 510 nm was expressed as 340/380 ratio to indicate intracellular Ca2+ levels. Application of 1 µM ionomycin in Ca2+-free tyrode solution released Ca2+ from intracellular stores, manifested as a transient peak in fluorescence ratio.

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Ionomycin increases flow of extracellular Ca2+ Into cells leading to increased T-cell activation by IFNg.
By Li Zhu on 01/23/2019
分析类型： In Vitro
种属： Human
细胞系/组织： Primary Cd8+ T-cells

Ionomycin was used as a calcium ionophore to bring large amounts of extracellular Ca2+ into activated CD8+ T-cells. With high intracellular Ca2+, this led to increased activation of CD8+ T-cells as measured by IFNg production via intracellular flow cytometry.

review image