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IOX 2

Cat. No. 4451 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
化学名： N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for IOX 2

IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 2 probe summary on the SGC website.

化合物库 for IOX 2

IOX 2 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for IOX 2

分子量 352.34
公式 C19H16N2O5
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 931398-72-0
PubChem ID 54685215
InChI Key CAOSCCRYLYQBES-UHFFFAOYSA-N
Smiles OC(C1=CC=CC=C1N2CC3=CC=CC=C3)=C(C(NCC(O)=O)=O)C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for IOX 2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.23 100

制备储备液 for IOX 2

以下数据基于产品分子量 352.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for IOX 2

参考文献是支持产品生物活性的出版物。

Murray et al (2010) Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J.Comb.Chem. 12 676 PMID: 20666436

If you know of a relevant reference for IOX 2, please let us know.

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关键词: IOX 2, IOX 2 supplier, supplier, IOX2, hypoxia, inducible, factor, 1, alpha, 1a, HIF1a, HIF1alpha, prolyl, hydroxylases, potent, inhibits, inhibitors, selective, cell, permeable, epigenetics, probe, JICL38, sgc, PHD2, Hydroxylases, Hypoxia, Inducible, Factors, 4451, Tocris Bioscience

2 篇 IOX 2 的引用文献

引用文献是使用了 Tocris 产品的出版物。 IOX 2 的部分引用包括：

Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261

Navdeep S et al (2021) Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway. Cell Rep 36 109547 PMID: 34407414

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