IP7e

Cat. No. 5699 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent Nurr1 activator

化学名： 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one

纯度： ≥98% (HPLC)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for IP7e

IP7e is a potent Nurr1 activator (EC₅₀ = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.

化合物库 for IP7e

IP7e is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for IP7e

分子量	390.43
公式	C₂₃H₂₂N₂O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	500164-74-9
PubChem ID	9908426
InChI Key	YCAACZFPADQMAR-UHFFFAOYSA-N
Smiles	CN1C(C2=CC=C(COCCOC)C=C2)=CC3=C(C(C4=CC=CC=C4)=NO3)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for IP7e

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	39.04	100
	ethanol	7.81	20 温和加热

制备储备液 for IP7e

以下数据基于产品分子量 390.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.81 mL	25.61 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for IP7e

分析证书/产品说明书

化学品安全技术说明书

参考文献 for IP7e

参考文献是支持产品生物活性的出版物。

Hintermann et al (2007) Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg.Med.Chem.Lett. 17 193 PMID: 17035009

Montarolo et al (2014) Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 9 e108791 PMID: 25265488

If you know of a relevant reference for IP7e, please let us know.

按标靶查看相关产品

关键词: IP7e, IP7e supplier, potent, Nurr1, activators, activates, orally, bioavailable, multiple, sclerosis, MS, EAE, experimental, autoimmune, encephalomyelitis, brain, penetrant, NF-KB, κ, signaling, isoxazolo-pyridinone, 7e, NF-kB/IkB, Nerve, Growth, Factor, IB-like, Receptors, 5699, Tocris Bioscience

篇 IP7e 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 IP7e 的引用文献。您是否知道使用了 Tocris IP7e 的优秀论文？请告知我们.

IP7e 的评论

目前没有该产品的评论。 Be the first to review IP7e and earn rewards!

Have you used IP7e?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for IP7e

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.