Iressa

Cat. No. 3000 21 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Orally active, selective EGFR inhibitor

别名： Gefitinib,ZD 1839

化学名： N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine

纯度： ≥98% (HPLC)

引用文献 (21)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Iressa

Iressa is an orally active, selective inhibitor of EGFR tyrosine kinase (IC₅₀ = 23 - 79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts. Also inhibits growth of brain metastases in mouse model of non-small cell lung cancer.

View information regarding the usage of Iressa for non-clinical studies.

许可信息

Sold for research purposes only under agreement from AstraZeneca

化合物库 for Iressa

Iressa is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Iressa

分子量	446.9
公式	C₂₂H₂₄ClFN₄O₃
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	184475-35-2
PubChem ID	123631
InChI Key	XGALLCVXEZPNRQ-UHFFFAOYSA-N
Smiles	FC(C=C3)=C(Cl)C=C3NC2=NC=NC1=CC(OC)=C(OCCCN4CCOCC4)C=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Iressa

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	44.69	100
	ethanol	4.47	10

制备储备液 for Iressa

以下数据基于产品分子量 446.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.19 mL	22.38 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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产品说明书 for Iressa

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Iressa

参考文献是支持产品生物活性的出版物。

Ciardiello et al (2000) Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin.Cancer Res. 6 2053 PMID: 10815932

Baselga et al (2000) ZD1839 ('Iressa'), as an anticancer agent. Drugs 60 33 PMID: 11129170

McKillop et al (2005) Tumor penetration of gefi. (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor. Mol.Cancer Ther. 4 641 PMID: 15827338

Tan et al (2017) Tyrosine kinase inhibitors show different anti-brain metastases efficacy in NSCLC: A direct comparative analysis of icotinib, gefitinib, and erlo. in a nude mouse model. Oncotarget. 8 98771 PMID: 29228726

If you know of a relevant reference for Iressa, please let us know.

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