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IT 901

Cat. No. 5846 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5846 has been discontinued.

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说明： NF-κB c-Rel subunit inhibitor
化学名： 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for IT 901

IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro. Reduces severity of graft-versus-host disease following hematopoietic stem cell transplant (HSCT) and inhibits growth of human B-cell lymphoma xenografts in mice. Inhibits the oxidative stress response in lymphoma cells.

技术数据 for IT 901

分子量 342.37
公式 C17H14N2O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1584121-99-2
PubChem ID 90082813
InChI Key JHOPCCOYRKEHQU-UHFFFAOYSA-N
Smiles COC1=C(C=CC=C2)C2=C(/C=C3C(NC(NC/3=O)=S)=O)C(OC)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for IT 901

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参考文献 for IT 901

参考文献是支持产品生物活性的出版物。

Shono et al (2016) Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-κB-controlled oxidative stress responses. Cancer Res. 76 377 PMID: 26744524

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关键词: IT 901, IT 901 supplier, IT901, NF-KB, NF-KappaB, NF-κB, c-Rel, subunit, inhibitors, inhibits, oxidative, stress, response, anticancer, NF-kB/IkB, 5846, Tocris Bioscience

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Pathways for IT 901

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.