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ITD 1

Cat. No. 5068 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs
化学名： 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (3)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ITD 1

ITD 1 is a selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

化合物库 for ITD 1

ITD 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ITD 1

分子量 415.52
公式 C27H29NO3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1099644-42-4
PubChem ID 44135961
InChI Key ULFUJLFTRWWLPO-UHFFFAOYSA-N
Smiles CC(C3)(C)CC(C1=C3NC(C)=C(C(OCC)=O)C1C2=CC=C(C4=CC=CC=C4)C=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ITD 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 8.31 20
ethanol 4.16 10 温和加热

制备储备液 for ITD 1

以下数据基于产品分子量 415.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 12.03 mL 60.17 mL 120.33 mL
1 mM 2.41 mL 12.03 mL 24.07 mL
2 mM 1.2 mL 6.02 mL 12.03 mL
10 mM 0.24 mL 1.2 mL 2.41 mL

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参考文献 for ITD 1

参考文献是支持产品生物活性的出版物。

Willems et al (2012) Small molecule-mediated TGF-beta type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell 11 242 PMID: 22862949

Kinney et al (2013) Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis. Trends Biotechnol. 31 78 PMID: 23219200

If you know of a relevant reference for ITD 1, please let us know.

按标靶查看相关产品

关键词: ITD 1, ITD 1 supplier, ITD1, selective, tgf-beta, tgf-b, tgf-β, signaling, pathway, inhibitors, inhibits, embryonic, stem, cells, cardiogenesis, cardiomyocytes, TGF-beta, Receptors, Cardiomyocyte, Stem, Cells, ESCs, and, iPSC, 5068, Tocris Bioscience

4 篇 ITD 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ITD 1 的部分引用包括：

Andrew R et al (2021) Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases. Commun Biol 4 950 PMID: 34376784

Chen et al (2021) Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment. Proc Natl Acad Sci U S A 118 PMID: 34244432

Smyth (2018) TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus. Int J Parasitol 48 379 PMID: 29510118

Yi-Wen et al (2020) TGF-β-driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model. JCI Insight 5 PMID: 32213706

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ITD 1 的评论

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for ITD 1

TGF-β Signaling Pathway

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.