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ITH 12575

Cat. No. 5692 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor
化学名： 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ITH 12575

ITH 12575 is a mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor. Reduces Ca2+ efflux from the mitochondria to the cytosol in HeLa cells (EC50 = 0.69 μM). Protects against glutamate-induced excitotoxitiy in rat hippocampal slices and oligomycin A/rotenone induced oxidative stress in neuroblastoma cells in vitro.

化合物库 for ITH 12575

ITH 12575 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ITH 12575

分子量 331.86
公式 C18H18ClNOS
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 1802013-08-6
PubChem ID 124201848
InChI Key RDMUJSJZBYAAEF-UHFFFAOYSA-N
Smiles O=C1NC2=CC=C(Cl)C=C2C(C3=C(C(C)C)C=CC=C3)SC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ITH 12575

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.19 100
ethanol 6.64 20

制备储备液 for ITH 12575

以下数据基于产品分子量 331.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.13 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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参考文献 for ITH 12575

参考文献是支持产品生物活性的出版物。

Martínez-Sanz et al (2015) Benzothiazepine CGP37157 analogues exert cytoprotection in various in vitro models of neurodegeneration. ACS Chem.Neurosci. 6 1626 PMID: 26192029

Moreno-Ortega et al (2015) Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology 95 503 PMID: 25908402

If you know of a relevant reference for ITH 12575, please let us know.

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关键词: ITH 12575, ITH 12575 supplier, ITH12575, sodium, calcium, exchangers, inhibitors, inhibits, Na+, Ca2+, exchange, neuroprotectant, neuroprotection, mitochondrial, mNCX, Na+/Ca2+, Exchanger, 5692, Tocris Bioscience

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