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说明： USP14 inhibitor
化学名： 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
纯度： ≥98% (HPLC)
生物活性 for IU1
Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). Stimulates proteasome activity and substrate degradation.
技术数据 for IU1
| 分子量 | 300.37 |
| 公式 | C18H21FN2O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 314245-33-5 |
| PubChem ID | 675434 |
| InChI Key | JUWDSDKJBMFLHE-UHFFFAOYSA-N |
| Smiles | O=C(CN2CCCC2)C1=C(C)N(C3=CC=C(F)C=C3)C(C)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for IU1
参考文献 for IU1
参考文献是支持产品生物活性的出版物。
Lee et al (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467 179 PMID: 20829789
Lee et al (2010) Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol.Cell.Proteomics 10 R110 PMID: 20823120
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关键词: IU1, IU1 supplier, selective, usp14, inhibitors, inhibits, proteasome, substrate, degradation, Deubiquitinating, Enzymes, 4088, Tocris Bioscience
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