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Ivermectin

Cat. No. 1260 5 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Positive allosteric modulator of α7 nAChRs; also positive allosteric modulator of P2X4 receptors
化学名： 22,23-Dihydroavermectin B1
纯度： ≥96% (HPLC)
说明书
引用文献 (5)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ivermectin

Ivermectin is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic and antiviral. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM). Inhibits replication of SARS-CoV-2 in vitro (IC50 ~ 2μM).

This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b.

技术数据 for Ivermectin

分子量 875.1
公式 C48H74O14 (B1a form)
储存 Desiccate at +4°C
纯度 ≥96% (HPLC)
CAS Number 70288-86-7
PubChem ID 6321424
InChI Key AZSNMRSAGSSBNP-XPNPUAGNSA-N
Smiles O[C@H]1[C@H](C)O[C@](O[C@H]2[C@@H](O[C@](O[C@H](/C(C)=C/C[C@@]4([H])O[C@@]7(CC[C@H](C)[C@@]([H])([C@]([H])(C)C)O7)C[C@@H]6C4)[C@@H](C)/C=C/C=C3/[C@]5(O)[C@]([C@H](O)C(C)=CC5C(O6)=O)([H])OC3)([H])C[C@@H]2OC)C)([H])C[C@@H]1OC.O[C@H]8[C@H](C)O[C@](O[C@H]9[C@@H](O[C@](O[C@H](/C(C)=C/C[C@@]%11([H])O[C@@]%14(CC[C@H](C)[C@@]([H])([C@]([H])(C)CC)O%14)C[C@@H]%13C%11)[C@@H](C)/C=C/C=C%10/[C@]%12(O)[C@]([C@H](O)C(C)=CC%12C(O%13)=O)([H])OC%10)([H])C[C@@H]9OC)C)([H])C[C@@H]8OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ivermectin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50

制备储备液 for Ivermectin

以下数据基于产品分子量 875.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 2.29 mL 11.43 mL 22.85 mL
2.5 mM 0.46 mL 2.29 mL 4.57 mL
5 mM 0.23 mL 1.14 mL 2.29 mL
25 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for Ivermectin

参考文献是支持产品生物活性的出版物。

Adelsberger et al (2000) Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide iverm. Eur.J.Pharmacol. 394 163 PMID: 10771281

Khakh et al (1999) Allosteric control of gating and kinetics at P2X4 receptor channels. J.Neurosci. 19 7289 PMID: 10460235

Krause et al (1998) Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol.Pharmacol. 53 283 PMID: 9463487

Shan et al (2001) Ivermectin, an unconventional agonist of the glycine receptor chloride channel. J.Biol.Chem. 276 12556 PMID: 11278873

Merck Index 12 5264

Caly et al (2020) The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 178 PMID: 32251768

If you know of a relevant reference for Ivermectin, please let us know.

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关键词: Ivermectin, Ivermectin supplier, Allosteric, modulators, α7, alpha7, nicotinic, receptors, Positive, allosteric, P2X4, Acetylcholine, nAChR, Purinergic, purinoceptors, PAM, SARS-CoV-2, COVID-19, antiviral, antiparasitic, P2X, Receptors, Nicotinic, (a7), Coronavirus, 1260, Tocris Bioscience

5 篇 Ivermectin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ivermectin 的部分引用包括：

Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435

Ren et al (2016) A biofidelic 3D culture model to study the development of brain cellular systems. Pharmacol Res Perspect 6 24953 PMID: 27112667

Dhuna et al (2019) Ginsenosides Act As Positive Modulators of P2X4 Receptors. Mol Pharmacol 95 210 PMID: 30545933

Fischer et al (2013) Natural compounds with P2X7 receptor-modulating properties. Purinergic Signal 10 313 PMID: 24163006

Nörenberg et al (2012) Positive allosteric modulation by iverm. of human but not murine P2X7 receptors. Br J Pharmacol 167 48 PMID: 22506590

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Ivermectin 的评论

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P2X4 potentiation.
By Anonymous on 10/02/2018
分析类型： In Vitro
种属： Mouse

Potentiates P2X4 responses in cultured microglia

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