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Submit ReviewIWP 4
说明： Potent inhibitor of Wnt/β-catenin signaling
化学名： N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
纯度： ≥98% (HPLC)
生物活性 for IWP 4
IWP 4 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
技术数据 for IWP 4
| 分子量 | 496.62 |
| 公式 | C23H20N4O3S3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 686772-17-8 |
| PubChem ID | 2155264 |
| InChI Key | RHUJMHOIQBDFQR-UHFFFAOYSA-N |
| Smiles | O=C1C3=C(CCS3)N=C(SCC(NC4=NC(C=CC(C)=C5)=C5S4)=O)N1C2=C(OC)C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for IWP 4
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 0.5 | 1 |
制备储备液 for IWP 4
以下数据基于产品分子量 496.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.01 mM | 201.36 mL | 1006.81 mL | 2013.61 mL |
| 0.05 mM | 40.27 mL | 201.36 mL | 402.72 mL |
| 0.1 mM | 20.14 mL | 100.68 mL | 201.36 mL |
| 0.5 mM | 4.03 mL | 20.14 mL | 40.27 mL |
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产品说明书 for IWP 4
参考文献 for IWP 4
参考文献是支持产品生物活性的出版物。
Lian et al (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc.Natl.Acad.Sci.U.S.A. 109 E1848-57 PMID: 22645348
Chen et al (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat.Chem.Biol. 5 100 PMID: 19125156
Narytnyk et al (2014) Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of DArgic neurons. Stem Cell Rev. 10 316 PMID: 24399192
Hoang et al (2018) Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells. Nat Protoc. 13 723 PMID: 29543795
Noor et al (2019) 3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts. Adv Sci (Weinh) 6 1900344 PMID: 31179230
If you know of a relevant reference for IWP 4, please let us know.
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关键词: IWP 4, IWP 4 supplier, IWP4, potent, inhibitors, inhibits, Wnt, beta-catenin, β-catenin, b-catenin, cardiomyocytes, ESCs, iPSCs, stem, cells, embryonic, pluripotent, differentiation, Beta-catenin, Cardiomyocyte, Stem, Cells, and, iPSC, Organoids, 5214, Tocris Bioscience
15 篇 IWP 4 的引用文献
引用文献是使用了 Tocris 产品的出版物。 IWP 4 的部分引用包括：
Sewanan et al (2019) Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes. JACC Basic Transl Sci 4 495 PMID: 31468004
Boroujeni et al (2019) Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo. Sci Rep 9 9750 PMID: 31278326
Parisa et al (2021) Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia. Curr Protoc 1 e320 PMID: 34958715
Esra et al (2021) Replating Protocol for Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Methods Mol Biol 2520 161-170 PMID: 34845657
J Travis et al (2021) Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2. Cell Rep 36 109512 PMID: 34380038
Andrew et al (2021) SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol 95 e0086221 PMID: 34260266
Paul et al (2021) Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Cell Rep 35 109088 PMID: 33951429
Jonathan G et al (2018) Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell 44 87-96.e5 PMID: 29316444
Wei et al (2018) iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications. Cell 173 851-863.e16 PMID: 29576452
Wai Hoe et al (2022) Co-differentiation and Co-maturation of Human Cardio-pulmonary Progenitors and Micro-Tissues from Human Induced Pluripotent Stem Cells. Bio Protoc 12 e4488 PMID: 36199699
Christine E et al (2022) Transcription factor protein interactomes reveal genetic determinants in heart disease. Cell 185 794-814.e30 PMID: 35182466
Kamil et al (2022) Engineering a living cardiac pump on a chip using high-precision fabrication. Sci Adv 8 eabm3791 PMID: 35452278
Ming et al (2022) Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells. Elife 11 PMID: 35018887
Joshy et al (2020) Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis. Mol Cell 80 648-665.e9 PMID: 33176162
Shiyong et al (2023) Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism. Nat Cell Biol PMID: 37264180
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