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J 2156

Cat. No. 6201 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective high affinity human sst4 agonist
化学名： (1'S,2S)-4-Amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4"-methyl-1"-naphthalenesulfonylamino)butanamide trifluoroacetate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for J 2156

J 2156 is a high affinity human somatostatin receptor 4 (sst4) agonist (Ki = 1.2 nM). Displays >400-fold selectivity for human sst4 over other human sst receptor subtypes. Exhibits 2 to 3-fold more potent agonism in vitro than endogenous ligands somatostatin-14 (Cat. No. 1157) and somatostatin-28 (Cat. No. 1165). Reduces inflammatory airway hyperresponsiveness in acute and chronic airway inflammation models in mice. Exhibits anxiolytic effects in elevated plus maze test in mice.

化合物库 for J 2156

J 2156 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for J 2156

分子量 582.6
公式 C24H28N4O4S.C2HF3O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2387505-73-7
PubChem ID 11442741
InChI Key VTNCZBXJSGKDLS-SFTDATJTSA-N
Smiles CC1=CC=C(S(=O)(N[C@H](C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)CCN)=O)C3=C1C=CC=C3.OC(C(F)(F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for J 2156

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 58.26 100
DMSO 58.26 100

制备储备液 for J 2156

以下数据基于产品分子量 582.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.72 mL 8.58 mL 17.16 mL
5 mM 0.34 mL 1.72 mL 3.43 mL
10 mM 0.17 mL 0.86 mL 1.72 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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参考文献 for J 2156

参考文献是支持产品生物活性的出版物。

Engström et al (2005) Superagonism at the human somatostatin receptor subtype 4. J.Pharmacol.Exp.Ther. 312 332 PMID: 15333679

Elekes et al (2008) Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 578 313 PMID: 17961545

Scheich et al (2016) Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models. Neuropharmacology. 101 204 PMID: 26387439

If you know of a relevant reference for J 2156, please let us know.

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关键词: J 2156, J 2156 supplier, J2156, human, somatostatin, receptor, 4, sst4, superagonist, agonists, agonism, 848647-56-3, anti-inflammatory, Somatostatin, Receptors, 6201, Tocris Bioscience

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