Jasplakinolide

Cat. No. 2792 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Stabilizes F-actin; promotes actin polymerization

化学名： Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]

纯度： ≥97% (HPLC)

引用文献 (10)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Jasplakinolide

Jasplakinolide rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (K_d ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC₅₀ = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.

技术数据 for Jasplakinolide

分子量	709.67
公式	C₃₆H₄₅BrN₄O₆
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	102396-24-7
PubChem ID	9831636
InChI Key	GQWYWHOHRVVHAP-DHKPLNAMSA-N
Smiles	C[C@H](C[C@H](C)OC1=O)/C=C(C)/C[C@H](C)C(N[C@H](C(N([C@H](CC2=C(Br)NC3=C2C=CC=C3)C(N[C@@H]([C@]4=CC=C(O)C=C4)C1)=O)C)=O)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Jasplakinolide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	2	3

制备储备液 for Jasplakinolide

以下数据基于产品分子量 709.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.03 mM	46.97 mL	234.85 mL	469.7 mL
0.15 mM	9.39 mL	46.97 mL	93.94 mL
0.3 mM	4.7 mL	23.49 mL	46.97 mL
1.5 mM	0.94 mL	4.7 mL	9.39 mL

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产品说明书 for Jasplakinolide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Jasplakinolide

参考文献是支持产品生物活性的出版物。

Cramer (1999) Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide. Curr.Biol. 9 1095 PMID: 10531004

Bubb et al (2000) Effects of jasplakinolide on the kinetics of actin polymerization. J.Biol.Chem. 275 5163 PMID: 10671562

Bubb et al (1995) Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J.Biol.Chem. 269 14869 PMID: 8195116

If you know of a relevant reference for Jasplakinolide, please let us know.

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关键词: Jasplakinolide, Jasplakinolide supplier, actin, f-actin, monomers, polymerization, polymerisation, stabilizers, stabilizes, inducers, induces, polymers, Actin, 2792, Tocris Bioscience