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JHW 007 hydrochloride

Cat. No. 4351 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity dopamine uptake inhibitor
化学名： (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JHW 007 hydrochloride

JHW 007 hydrochloride is a dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (Ki = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.

化合物库 for JHW 007 hydrochloride

JHW 007 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for JHW 007 hydrochloride

分子量 421.95
公式 C24H29F2NO.HCl
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 202645-74-7
PubChem ID 71771746
InChI Key RHYMGBAYGRUKNZ-DHWZJIOFSA-N
Smiles [H][C@@]12CC[C@@](C[C@H](OC(C4=CC=C(F)C=C4)C3=CC=C(F)C=C3)C2)([H])N1CCCC.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JHW 007 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.19 100
ethanol 42.19 100

制备储备液 for JHW 007 hydrochloride

以下数据基于产品分子量 421.95。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.85 mL 23.7 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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产品说明书 for JHW 007 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for JHW 007 hydrochloride

参考文献是支持产品生物活性的出版物。

Kristensen et al (2011) SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacol.Rev. 63 585 PMID: 21752877

Kopajtic et al (2010) DA transporter-dependent and -independent striatal binding of the benztr. analog JHW 007, a cocaine antagonist with low abuse liability. J.Pharmacol.Exp.Ther. 335 703 PMID: 20855444

Velaquez-Sanchez et al (2010) The high affinity DA uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization. Eur.Neuropsychopharmacol. 20 501 PMID: 20413276

Hiranita et al (2014) Preclinical efficacy of N-substituted benztr. analogs as antagonists of metha. self-administration in rats. J.Pharmacol.Exp.Ther. 348 174 PMID: 24194527

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关键词: JHW 007 hydrochloride, JHW 007 hydrochloride supplier, JHW007, dopamine, uptake, inhibitors, inhibits, DAT, transporter, Dopamine, Transporters, 4351, Tocris Bioscience

1 篇 JHW 007 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 JHW 007 hydrochloride 的部分引用包括：

Andersen et al (2015) Binding site residues control inhibitor selectivity in the human NE transporter but not in the human DA transporter. Stem Cell Reports 5 15650 PMID: 26503701

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