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Submit ReviewJK 184
说明： Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway
化学名： N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine
纯度： ≥99% (HPLC)
生物活性 for JK 184
JK 184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.
技术数据 for JK 184
| 分子量 | 350.44 |
| 公式 | C19H18N4OS |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 315703-52-7 |
| PubChem ID | 1069686 |
| InChI Key | ROYXIPOUVGDTAO-UHFFFAOYSA-N |
| Smiles | CC2=C(C3=CSC(NC4=CC=C(OCC)C=C4)=N3)N1C=CC=CC1=N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for JK 184
参考文献 for JK 184
参考文献是支持产品生物活性的出版物。
Lee et al (2007) A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem. 8 1916 PMID: 17886323
Cupido et al (2009) The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling. Angew.Chem.Int.Ed.Engl. 48 2321 PMID: 19222062
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关键词: JK 184, JK 184 supplier, Alcohol, dehydrogenase, 7, inhibitors, inhibits, downstream, Hh, signaling, pathway, Signalling, Hedgehog, Gli, JK184, stem, cells, Signaling, Dehydrogenase, Stem, Cell, 3341, Tocris Bioscience
1 篇 JK 184 的引用文献
引用文献是使用了 Tocris 产品的出版物。 JK 184 的部分引用包括：
Oladapo (2017) Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett 411 136 PMID: 28965853
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