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Submit ReviewJMV 449
说明： Potent neurotensin receptor agonist
纯度： ≥95% (HPLC)
生物活性 for JMV 449
JMV 449 is a potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.
技术数据 for JMV 449
| 分子量 | 746.96 |
| 公式 | C38H66N8O7 |
| 序列 |
KKPYIL (Modifications: Lys-1 - Lys-2 peptide bond replaced with Ψ(CH2-NH)) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 139026-66-7 |
| PubChem ID | 164415 |
| InChI Key | TZCYVPLNMOJUIL-GULBXNHPSA-N |
| Smiles | [H]N[C@@H](CCCCN)CN[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for JMV 449
| 溶解性 | Soluble to 0.80 mg/ml in water |
产品说明书 for JMV 449
参考文献 for JMV 449
参考文献是支持产品生物活性的出版物。
Lugrin et al (1991) Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 205 191 PMID: 1812009
Dubuc et al (1992) JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 219 327 PMID: 1425958
Torup et al (2003) Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 351 173 PMID: 14623134
If you know of a relevant reference for JMV 449, please let us know.
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关键词: JMV 449, JMV 449 supplier, Potent, neurotensin, receptor, agonists, NT, Receptors, JMV449, Neurotensin, 1998, Tocris Bioscience
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.