Neurotensin Receptors
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1).
Neurotensin Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1998 | JMV 449 |
| Potent neurotensin receptor agonist | |
| 1909 | Neurotensin |
| Endogenous neurotransmitter and endocrine modulator | |
Partial Agonists |
|
| Cat. No. | Product Name / Activity |
| 5087 | TC NTR1 17 |
| Selective NTS1 partial agonist | |
Neurotensin Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 5438 | NTRC 824 |
| Potent and selective non-peptide NTS2 antagonist | |
| 2309 | SR 142948 |
| Highly potent NTS receptor antagonist | |
| 3721 | SR 48692 |
| Selective non-peptide NTS1 antagonist | |
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the digestive tract and hypothermic and analgesic effects.
NTS1 is distributed widely throughout the brain and gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2 receptors are located on chromosomes 20q13 and 2p25.1 respectively.
External sources of pharmacological information for Neurotensin Receptors :
Literature for Neurotensin Receptors
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Peptides Involved in Appetite Modulation Scientific Review
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