JNJ 28871063 hydrochloride

Cat. No. 3352 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent ErbB receptor family inhibitor

化学名： 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride

纯度： ≥97% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for JNJ 28871063 hydrochloride

JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor (IC₅₀ values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC₅₀ = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active.

化合物库 for JNJ 28871063 hydrochloride

JNJ 28871063 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for JNJ 28871063 hydrochloride

分子量	519.42
公式	C₂₄H₂₇ClN₆O₃.HCl
储存	Desiccate at +4°C
纯度	≥97% (HPLC)
CAS Number	944342-90-9
PubChem ID	17747413
InChI Key	ZXKZRKQMKNRZNN-GZPZNDDGSA-N
Smiles	NC1=C(/C=N/OCCN2CCOCC2)C(NC3=CC(Cl)=C(OCC4=CC=CC=C4)C=C3)=NC=N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JNJ 28871063 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	25.97	50

制备储备液 for JNJ 28871063 hydrochloride

以下数据基于产品分子量 519.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.85 mL	19.25 mL	38.5 mL
2.5 mM	0.77 mL	3.85 mL	7.7 mL
5 mM	0.39 mL	1.93 mL	3.85 mL
25 mM	0.08 mL	0.39 mL	0.77 mL

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产品说明书 for JNJ 28871063 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for JNJ 28871063 hydrochloride

参考文献是支持产品生物活性的出版物。

Contessa and Hamstra (2008) Revoking the privilege: targeting HER2 in the central nervous system. Mol.Pharmacol. 73 271 PMID: 17981994

Emanuel et al (2008) Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol.Pharmacol. 73 338 PMID: 17975007

Guessous et al (2008) Signaling pathways in medulloblastoma. J.Cell.Phys. 217 577 PMID: 18651559

If you know of a relevant reference for JNJ 28871063 hydrochloride, please let us know.

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