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说明： Selective NPY Y2 receptor antagonist
化学名： (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide
纯度： ≥98% (HPLC)
生物活性 for JNJ 5207787
JNJ 5207787 is a selective NPY Y2 antagonist (IC50 = 0.1 μM). Displays 100-fold selectivity over NPY Y1, Y4 and Y5 receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.
许可信息
Sold with the permission of Janssen Pharmaceutica N.V.
技术数据 for JNJ 5207787
| 分子量 | 510.67 |
| 公式 | C32H38N4O2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 683746-68-1 |
| PubChem ID | 10324083 |
| InChI Key | DSEJCLDJIFTPPH-FMIVXFBMSA-N |
| Smiles | O=C(C)N2CCC1=CC=C(N(C(/C=C/C5=CC=CC(C#N)=C5)=O)C3CCN(CCC4CCCC4)CC3)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for JNJ 5207787
参考文献 for JNJ 5207787
参考文献是支持产品生物活性的出版物。
Bonaventure et al (2004) Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J.Pharmacol.Exp.Ther. 308 1130 PMID: 14617685
Jablonowski et al (2004) Novel non-peptide neuropeptide Y Y2 receptor antagonists. Bioorg.Med.Chem.Lett. 14 1239 PMID: 14980673
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关键词: JNJ 5207787, JNJ 5207787 supplier, JNJ5207787, neuropeptide, y, NPY, Y2, antagonists, selective, Receptors, 4018, Tocris Bioscience
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