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JNJ 63533054

Cat. No. 5666 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective GPR139 agonist
化学名： 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JNJ 63533054

JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.

化合物库 for JNJ 63533054

JNJ 63533054 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for JNJ 63533054

分子量 316.78
公式 C17H17ClN2O2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 1802326-66-4
PubChem ID 2548547
InChI Key MWDVCHRYCKXEBY-LBPRGKRZSA-N
Smiles O=C(CNC(C1=CC=CC(Cl)=C1)=O)N[C@@H](C)C2=CC=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JNJ 63533054

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 31.68 100
ethanol 6.34 20

制备储备液 for JNJ 63533054

以下数据基于产品分子量 316.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.78 mL 31.57 mL
5 mM 0.63 mL 3.16 mL 6.31 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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参考文献 for JNJ 63533054

参考文献是支持产品生物活性的出版物。

Dvorak et al (2015) Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor. ACS Med.Chem.Lett. 6 1015 PMID: 26396690

If you know of a relevant reference for JNJ 63533054, please let us know.

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关键词: JNJ 63533054, JNJ 63533054 supplier, JNJ63533054, GPR139, agonists, agonism, potent, selective, orally, available, brain, penetrant, orphan, 7-TM, receptors, Orphan, Receptors, 5666, Tocris Bioscience

1 篇 JNJ 63533054 的引用文献

引用文献是使用了 Tocris 产品的出版物。 JNJ 63533054 的部分引用包括：

Susumu et al (2021) Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway. iScience 24 102504 PMID: 34113835

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