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JTP 103237

Cat. No. 6765 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6765 has been discontinued.

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说明： Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor
化学名： 7-[4,6-Bis(1,1-dimethylethyl)-2-pyrimidinyl]-5,6,7,8-tetrahydro-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazolo[4,3-a]pyrazine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for JTP 103237

JTP 103237 is a potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor (IC50 = 20 - 40 nM). Displays >7000-fold selectivity for human MOGAT2 over human DGAT2. Modulates intestinal lipid absorption in mice. Decreases triglyceride, diacylglycerol and fatty acid synthesis in mouse model of fatty liver. Chronic treatment decreases hepatic triglyceride content and body weight, and improves glucose tolerance in diet-induced obese mice.

化合物库 for JTP 103237

JTP 103237 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for JTP 103237

分子量 474.52
公式 C24H29F3N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1883864-16-1
PubChem ID 91884614
InChI Key KELNXHBJTXCXSN-UHFFFAOYSA-N
Smiles CC(C)(C1=CC(C(C)(C)C)=NC(N2CCN3C(C2)=NN=C3C4=CC=C(C=C4)OC(F)(F)F)=N1)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for JTP 103237

参考文献是支持产品生物活性的出版物。

Okuma et al (2015) JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity. Eur.J.Pharmacol. 758 72 PMID: 25857225

Okuma et al (2015) JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis. J.Pharmacol.Sci. 128 150 PMID: 26215699

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关键词: JTP 103237, JTP 103237 supplier, JTP103237, monoacyglycerol, acyltransferase, MGAT2, inhibitors, inhibits, potent, selective, antiobesity, triglyceride, synthesis, DGAT2L, MOGAT2, Other, Transferases, Lipid, Metabolism, 6765, Tocris Bioscience

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