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JW 67

Cat. No. 4651 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4651 has been discontinued.

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说明： Wnt pathway inhibitor; induces degradation of active β-catenin
化学名： Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione
纯度： ≥97% (HPLC)
说明书
引用文献
评论 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for JW 67

JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 μM).

化合物库 for JW 67

JW 67 is also offered as part of the Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for JW 67

分子量 394.38
公式 C21H18N2O6
储存 Store at +4°C
纯度 ≥97% (HPLC)
CAS Number 442644-28-2
PubChem ID 644733
InChI Key BTXRSHKJNDFHGA-UHFFFAOYSA-N
Smiles O=C1NC6=C(C=CC=C6)C21OCC3(COC(C(NC5=C4C=CC=C5)=O)4OC3)CO2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for JW 67

参考文献是支持产品生物活性的出版物。

Shultz et al (2012) [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J.Med.Chem. 55 1127 PMID: 22260203

Waaler et al (2011) Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 71 197 PMID: 21199802

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关键词: JW 67, JW 67 supplier, JW67, canonical, Wnt, pathway, signaling, inhibitors, inhibits, beta, b, β, catenin, proliferation, selective, Other, Signaling, Beta-catenin, 4651, Tocris Bioscience

篇 JW 67 的引用文献

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JW 67 的评论

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Induces beta-Catenin degradation.
By Anonymous on 02/10/2023
分析类型： In Vitro
种属： Human
细胞系/组织： HepG2, and Huh,

When treated in to hepatoma cells (0.5uM) for 48 hours, it substantially induced the degradation of b catenin.

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Pathways for JW 67

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.