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Submit ReviewJZL 195
说明： Dual FAAH and MAGL inhibitor
化学名： 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
纯度： ≥98% (HPLC)
生物活性 for JZL 195
JZL 195 is a dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown to impair short-term memory in mice.
化合物库 for JZL 195
JZL 195 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for JZL 195
| 分子量 | 433.46 |
| 公式 | C24H23N3O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1210004-12-8 |
| PubChem ID | 46232606 |
| InChI Key | QNYRAEKLMNDRFY-UHFFFAOYSA-N |
| Smiles | O=C(OC4=CC=C([N+]([O-])=O)C=C4)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for JZL 195
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 21.67 | 50 |
制备储备液 for JZL 195
以下数据基于产品分子量 433.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.61 mL | 23.07 mL | 46.14 mL |
| 2.5 mM | 0.92 mL | 4.61 mL | 9.23 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
| 25 mM | 0.09 mL | 0.46 mL | 0.92 mL |
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产品说明书 for JZL 195
参考文献 for JZL 195
参考文献是支持产品生物活性的出版物。
Wise et al (2012) Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS Chem.Neurosci. 3 369 PMID: 22860205
Long et al (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc.Natl.Acad.Sci.USA 106 20270 PMID: 19918051
Wiskerke et al (2012) Characterization of the effects of reuptake and hydrolysis inhibiton on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem.Neurosci. 3 407 PMID: 22860210
If you know of a relevant reference for JZL 195, please let us know.
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关键词: JZL 195, JZL 195 supplier, JZL195, FAAH, fatty, acid, amide, hydrolase, monoacylglycerol, lipase, MAGL, inhibitors, inhibits, dual, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4715, Tocris Bioscience
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