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Submit ReviewK 02288
说明： Type 1 BMP receptor inhibitor
别名： K 02288a
化学名： 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
纯度： ≥99% (HPLC)
生物活性 for K 02288
K 02288 is a potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.
化合物库 for K 02288
K 02288 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
技术数据 for K 02288
| 分子量 | 352.38 |
| 公式 | C20H20N2O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1431985-92-0 |
| PubChem ID | 46173038 |
| InChI Key | CJLMANFTWLNAKC-UHFFFAOYSA-N |
| Smiles | NC1=NC=C(C3=CC=CC(O)=C3)C=C1C2=CC(OC)=C(OC)C(OC)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for K 02288
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 35.24 | 100 | |
| ethanol | 3.52 | 10 温和加热 |
制备储备液 for K 02288
以下数据基于产品分子量 352.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.19 mL | 28.38 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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产品说明书 for K 02288
参考文献 for K 02288
参考文献是支持产品生物活性的出版物。
Sanvitale et al (2013) A new class of small molecule inhibitor of BMP signaling. PLoS ONE 8 62721 PMID: 23646137
Mohedas et al (2013) Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 8 1291 PMID: 23547776
If you know of a relevant reference for K 02288, please let us know.
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关键词: K 02288, K 02288 supplier, potent, selective, bone, morphogenic, protein, BMP, ALK2, inhibitors, inhibits, K02288, K02288a, K, 02288a, and, Other, Activin, Receptors, 4986, Tocris Bioscience
3 篇 K 02288 的引用文献
引用文献是使用了 Tocris 产品的出版物。 K 02288 的部分引用包括：
Bui et al (2017) Transient exposure to androgens induces a remarkable self-sustained quiescent state in dispersed prostate cancer cells. Cell Cycle 16 879 PMID: 28426320
Bui et al (2015) SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy. Cell Cycle 14 1218 PMID: 25706341
Wendy B et al (2020) The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. Glia 68 1274-1290 PMID: 31904150
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for K 02288
