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K 03861

Cat. No. 6789 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent CDK2 inhibitor
别名： AUZ 454
化学名： N-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for K 03861

K 03861 is a potent Cdk2 inhibitor (Kd values are 9.7, 15.4, 18.6 and 50 nM at Cdk2 (C118L/A144C), Cdk2 (A144C), Cdk2 (C118L), and Cdk (WT) respectively. Competes with cyclin binding to inhibit Cdk2 kinase activity in vitro.

化合物库 for K 03861

K 03861 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for K 03861

分子量 501.51
公式 C24H26F3N7O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 853299-07-7
InChI Key PWDLXPJQFNVTNL-UHFFFAOYSA-N
Smiles CN1CCN(CC2=C(C=C(NC(=O)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)C=C2)C(F)(F)F)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for K 03861

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.08 50
ethanol 50.15 100

制备储备液 for K 03861

以下数据基于产品分子量 501.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for K 03861

参考文献是支持产品生物活性的出版物。

Song et al (2017) NEUROG1 regulates CDK2 to promote proliferation in otic progenitors Stem Cell Reports 9 1516 PMID: 29033307

Alexander et al (2015) Type II inhibitors targeting Cdk2 ACS.Chem.Biol 10 2116 PMID: 26158339

If you know of a relevant reference for K 03861, please let us know.

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关键词: K 03861, K 03861 supplier, AUZ454, potent, Cdk2, inhibitors, inhibits, cyclin-dependent, protein, kinases, AUZ, 454, Cyclin-dependent, Kinase, CDK1, Subfamily, 6789, Tocris Bioscience

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