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K 858

Cat. No. 3703 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3703 has been discontinued.

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说明： Selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor
化学名： N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
纯度： ≥99% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for K 858

K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM). Induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells. Displays no effect on microtubule dynamics. Preferentially induces mitotic arrest in cancer cells.

技术数据 for K 858

分子量 277.34
公式 C13H15N3O2S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 72926-24-0
PubChem ID 2930014
InChI Key JEFVYQYZCAVNTP-UHFFFAOYSA-N
Smiles CC1(C2=CC=CC=C2)N(C(C)=O)N=C(NC(C)=O)S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for K 858

参考文献是支持产品生物活性的出版物。

Nakai et al (2009) K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 69 3901 PMID: 19351824

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关键词: K 858, K 858 supplier, mitotic, kinesin, Eg5, inhibitors, inhibits, cytoskeleton, motor, proteins, ATPase, K858, Kinesin, 3703, Tocris Bioscience

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