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Submit ReviewKC7F2
说明： HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
化学名： N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
纯度： ≥98% (HPLC)
生物活性 for KC7F2
KC7F2 is an inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.
技术数据 for KC7F2
| 分子量 | 570.38 |
| 公式 | C16H16Cl4N2O4S4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 927822-86-4 |
| PubChem ID | 16047442 |
| InChI Key | REQLACDIZMLXIC-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(Cl)C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for KC7F2
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 57.04 | 100 |
制备储备液 for KC7F2
以下数据基于产品分子量 570.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.75 mL | 8.77 mL | 17.53 mL |
| 5 mM | 0.35 mL | 1.75 mL | 3.51 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.75 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
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产品说明书 for KC7F2
参考文献 for KC7F2
参考文献是支持产品生物活性的出版物。
Narita et al (2009) Identification of a novel small molecule HIF-1α translation inhibitor. Clin.Cancer Res. 15 6128 PMID: 19789328
Koh et al (2009) Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin.Cancer Res. 15 5945 PMID: 19789327
If you know of a relevant reference for KC7F2, please let us know.
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关键词: KC7F2, KC7F2 supplier, KC7F2, HIF-1a, HIF-1alpha, HIF-1α, inhibitors, inhibits, hypoxia-inducible, factors, downregulators, down-regulators, downregulation, down-regulation, Hypoxia, Inducible, Factors, 4324, Tocris Bioscience
2 篇 KC7F2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 KC7F2 的部分引用包括：
Hannes M et al (2020) LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes. Front Immunol 11 353 PMID: 32210962
Dean H et al (2020) Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts. Sci Rep 10 8388 PMID: 32433492
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
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- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
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