KC7F2

Cat. No. 4324 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： HIF-1α inhibitor; down-regulates HIF-1α protein synthesis

化学名： N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for KC7F2

KC7F2 is an inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.

技术数据 for KC7F2

分子量	570.38
公式	C₁₆H₁₆Cl₄N₂O₄S₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	927822-86-4
PubChem ID	16047442
InChI Key	REQLACDIZMLXIC-UHFFFAOYSA-N
Smiles	ClC1=CC=C(Cl)C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KC7F2

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	57.04	100

制备储备液 for KC7F2

以下数据基于产品分子量 570.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.75 mL	8.77 mL	17.53 mL
5 mM	0.35 mL	1.75 mL	3.51 mL
10 mM	0.18 mL	0.88 mL	1.75 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for KC7F2

分析证书/产品说明书

化学品安全技术说明书

参考文献 for KC7F2

参考文献是支持产品生物活性的出版物。

Narita et al (2009) Identification of a novel small molecule HIF-1α translation inhibitor. Clin.Cancer Res. 15 6128 PMID: 19789328

Koh et al (2009) Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin.Cancer Res. 15 5945 PMID: 19789327

If you know of a relevant reference for KC7F2, please let us know.

按标靶查看相关产品

关键词: KC7F2, KC7F2 supplier, KC7F2, HIF-1a, HIF-1alpha, HIF-1α, inhibitors, inhibits, hypoxia-inducible, factors, downregulators, down-regulators, downregulation, down-regulation, Hypoxia, Inducible, Factors, 4324, Tocris Bioscience

2 篇 KC7F2 的引用文献

引用文献是使用了 Tocris 产品的出版物。 KC7F2 的部分引用包括：

Hannes M et al (2020) LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes. Front Immunol 11 353 PMID: 32210962

Dean H et al (2020) Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts. Sci Rep 10 8388 PMID: 32433492

您是否知道使用了 Tocris KC7F2 的优秀论文？请告知我们.

KC7F2 的评论

目前没有该产品的评论。 Be the first to review KC7F2 and earn rewards!

Have you used KC7F2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Glycolysis
Tricarboxylic Acid Cycle
Lipidogenesis
1C Metabolism and Nucleic Acid Synthesis
Drivers of Metabolic Reprogramming
pH and Redox Balance

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.