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Ki 20227

Cat. No. 4481 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation
化学名： N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ki 20227

Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses osteoclast differentiation and osteolysis in a rat bone metastasis model.

化合物库 for Ki 20227

Ki 20227 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Ki 20227

分子量 480.54
公式 C24H24N4O5S
储存 Store at +4°C
纯度 ≥97% (HPLC)
CAS Number 623142-96-1
PubChem ID 9869779
InChI Key SHPFDGWALWEPGS-UHFFFAOYSA-N
Smiles O=C(NC(C)C3=NC=CS3)NC(C(OC)=C2)=CC=C2OC1=C4C(C=C(OC)C(OC)=C4)=NC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ki 20227

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 48.05 100

制备储备液 for Ki 20227

以下数据基于产品分子量 480.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.4 mL 20.81 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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产品说明书 for Ki 20227

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Ki 20227

参考文献是支持产品生物活性的出版物。

Kubota et al (2009) M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J.Exp.Med. 206 1089 PMID: 19398755

Ohno et al (2007) The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model. Eur.J.Immunol. 38 283 PMID: 18085662

Ohno et al (2006) A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol.Cancer Ther. 5 2634 PMID: 17121910

If you know of a relevant reference for Ki 20227, please let us know.

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关键词: Ki 20227, Ki 20227 supplier, Ki20227, c-Fms, macrophage, colony-stimulating, factor, receptors, M-CSFR, CSF1R, inhibitors, inhibits, osteolysis, osteoclasts, Other, RTKs, 4481, Tocris Bioscience

1 篇 Ki 20227 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ki 20227 的部分引用包括：

Barnett et al (2016) Macrophages form functional vascular mimicry channels in vivo. Sci Rep 6 36659 PMID: 27834402

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