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Kinesore

Cat. No. 6664 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Kinesin-1 modulator; cell permeable
化学名： 3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Kinesore

Kinesore is a kinesin-1 modulator. Inhibits SKIP-KLC2 interaction, but promotes kinesin-1 function in controlling the organization of the microtubule network. Induces remodeling of the microtubule network and the formation of extensive microtubule-rich projections. Cell permeable.

技术数据 for Kinesore

分子量 536.17
公式 C20H16Br2N4O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 363571-83-9
PubChem ID 5507411
InChI Key DUGCMEGLYHBMAR-RMORIDSASA-N
Smiles CC1=CC(/C=N/NC(C2=CC(Br)=C(C(Br)=C2)O)=O)=C(N1C3=CC([N+]([O-])=O)=CC=C3)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Kinesore

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 53.62 100

制备储备液 for Kinesore

以下数据基于产品分子量 536.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.33 mL 18.65 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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参考文献 for Kinesore

参考文献是支持产品生物活性的出版物。

Randall et al (2017) A small-molecule activator of kinesin-1 drives remodeling of the microtubule network. Proc.Natl.Acad.Sci.USA 114 13743 PMID: 29229862

If you know of a relevant reference for Kinesore, please let us know.

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关键词: Kinesore, Kinesore supplier, Kinesin-1, modulators, modulates, SKIP-KLC2, microtubule, remodeling, cell, permeable, Kinesin, 6664, Tocris Bioscience

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