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KL 001

Cat. No. 4685 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cryptochrome protein stabilizer; lengthens circadian period
化学名： N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for KL 001

KL 001 is a cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.

技术数据 for KL 001

分子量 398.48
公式 C21H22N2O4S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 309928-48-1
PubChem ID 2888648
InChI Key OQAFDLPAPSSOHY-UHFFFAOYSA-N
Smiles OC(CN(CC4=CC=CO4)S(C)(=O)=O)CN2C1=CC=CC=C1C3=C2C=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KL 001

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.85 100
ethanol 7.97 20

制备储备液 for KL 001

以下数据基于产品分子量 398.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for KL 001

参考文献是支持产品生物活性的出版物。

Hirota et al (2012) Identification of small molecule activators of cryptochrome. Science 337 1094 PMID: 22798407

If you know of a relevant reference for KL 001, please let us know.

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关键词: KL 001, KL 001 supplier, KL001, cryptochrome, stabilizers, CRY, CRY1, CRY2, circadian, clock, rhythms, gluconeogenesis, regulator, Other, Transcription, Factors, 4685, Tocris Bioscience

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