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Submit ReviewKN 92
说明： Inactive analog of KN 93. K+ channel (Kv) blocker
化学名： 2-[N-(4'-Methoxybenzenesulfonyl)]amino-N-(4'-chlorophenyl)-2-propenyl-N-methylbenzylamine phosphate
纯度： ≥98% (HPLC)
生物活性 for KN 92
KN 92 is an inactive analog of the CaM kinase II inhibitor KN 93 . Potassium channel (Kv1.2, 1.4, 1.5, 2.1, 3.2 and hERG) blocker in vitro.
Active Analog also available.
技术数据 for KN 92
| 分子量 | 554.98 |
| 公式 | C24H25ClN2O3S.H3PO4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1135280-28-2 |
| PubChem ID | 16219540 |
| InChI Key | XRQHWVVDNMJDEQ-IPZCTEOASA-N |
| Smiles | ClC1=CC=C(/C=C/CN(C)CC2=CC=CC=C2NS(=O)(C3=CC=C(OC)C=C3)=O)C=C1.OP(O)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for KN 92
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 5.55 | 10 |
制备储备液 for KN 92
以下数据基于产品分子量 554.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.02 mL | 90.09 mL | 180.19 mL |
| 0.5 mM | 3.6 mL | 18.02 mL | 36.04 mL |
| 1 mM | 1.8 mL | 9.01 mL | 18.02 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
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产品说明书 for KN 92
参考文献 for KN 92
参考文献是支持产品生物活性的出版物。
Rezazadeh et al (2005) KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 317 292 PMID: 16368898
If you know of a relevant reference for KN 92, please let us know.
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关键词: KN 92, KN 92 supplier, potassium, K+, blockers, Kv, channels, inactive, analog, KN93, KN92, calcium, binding, protein, modulators, voltage-gated, hERG, Human, Ether-A-Go-Go, Gene, voltage-dependent, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Ca2+, Binding, Calcium, Protein, Voltage-Gated, Potassium, Channels, 4130, Tocris Bioscience
5 篇 KN 92 的引用文献
引用文献是使用了 Tocris 产品的出版物。 KN 92 的部分引用包括：
Kurt F et al (2019) Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions. J Neurochem 149 98-110 PMID: 30674062
Hongwei et al (2020) Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models. Sci Transl Med 12 PMID: 32641489
Weng et al (2017) An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron 94 337 PMID: 28426967
Thomas et al (2021) Amyloid-Beta Mediates Homeostatic Synaptic Plasticity. J Neurosci 41 5157-5172 PMID: 33926999
Seto et al (2013) Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes. Oncotarget 8 e66404 PMID: 23799098
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KN 92 的评论
平均评分: 5 (Based on 1 Review.)
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KN93 but not KN92 reduces maximum upstroke velocity of cardiac action potential.
By
Christopher Trummer on 10/22/2018
分析类型： In Vitro
种属： Other
细胞系/组织： Cardiomyocytes
Guinea pig ventricular cardiomyocytes were treated (12-16 h) with KN93 (5 µM), KN92 (5 µM) or Ranolazine (10 µM). Cells were patched and stimulated at a 1 Hz frequency to record action potential. Maximum upstroke velocity was significantly was reduced by KN93 while KN92 was ineffective.
