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KW 3902

Cat. No. 4167 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective A1 antagonist
别名： Rolofylline
化学名： 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for KW 3902

KW 3902 is a selective adenosine A1 receptor antagonist; displays 890-fold selectivity for rat A1 receptors over A2A receptors (Ki values are 0.19 and 170 nM respectively). Displays no effect on recombinant rat A3 receptors expressed on CHO cells at concentrations up to 10 μM. Exhibits diuretic and renal protective effects in rats.

化合物库 for KW 3902

KW 3902 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for KW 3902

分子量 356.46
公式 C20H28N4O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 136199-02-5
PubChem ID 64627
InChI Key PJBFVWGQFLYWCB-UHFFFAOYSA-N
Smiles O=C1C2=C(NC(C34CC(CC4C5)CC5C3)=N2)N(CCC)C(N1CCC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KW 3902

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.82 50
ethanol 8.91 25

制备储备液 for KW 3902

以下数据基于产品分子量 356.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.61 mL 28.05 mL 56.11 mL
2.5 mM 1.12 mL 5.61 mL 11.22 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
25 mM 0.11 mL 0.56 mL 1.12 mL

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参考文献 for KW 3902

参考文献是支持产品生物活性的出版物。

Shimada et al (1992) 8-polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. J.Med.Chem. 35 924 PMID: 1548682

Nonaka et al (1996) KW-3902, a selective high affinity antagonist for adenosine A1 receptors. Br.J.Pharmacol. 117 1645 PMID: 8732272

Nishiyama et al (1999) Adenosine A1 receptor antagonist KW-3902 prevents hypoxia-induced renal vasoconstriction. J.Pharmacol.Exp.Ther. 291 988 PMID: 10565815

If you know of a relevant reference for KW 3902, please let us know.

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关键词: KW 3902, KW 3902 supplier, adenosine, a1, antagonists, selective, KW3902, Rolofylline, Adenosine, A1, Receptors, 4167, Tocris Bioscience

1 篇 KW 3902 的引用文献

引用文献是使用了 Tocris 产品的出版物。 KW 3902 的部分引用包括：

Cheng et al (2017) Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure 25 1275 PMID: 28712806

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KW 3902 的评论

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systemic administration of KW3902.
By Ariel Vitenzon on 01/05/2018
分析类型： In Vivo
种属： Mouse

We injected this drug at 1 mg/Kg and 2 mg/Kg systemically (IP) into transgenic mice and monitored the effect on motor behavior. The drug efficiently induced motor symptoms in the transgenic mice at these concentrations.

The drug dissolves well in saline + 0.3% tween 80 with 3X vortex (1min) and sonicate (5min).