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Submit ReviewKY 02111
说明： Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
化学名： N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
纯度： ≥98% (HPLC)
生物活性 for KY 02111
KY 02111 promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.
化合物库 for KY 02111
KY 02111 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for KY 02111
| 分子量 | 376.86 |
| 公式 | C18H17ClN2O3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1118807-13-8 |
| PubChem ID | 8582409 |
| InChI Key | LXFKEVQQSKQXPR-UHFFFAOYSA-N |
| Smiles | O=C(CCC3=CC=C(OC)C(OC)=C3)NC2=NC1=CC=C(Cl)C=C1S2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for KY 02111
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 18.84 | 50 |
制备储备液 for KY 02111
以下数据基于产品分子量 376.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.31 mL | 26.54 mL | 53.07 mL |
| 2.5 mM | 1.06 mL | 5.31 mL | 10.61 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.31 mL |
| 25 mM | 0.11 mL | 0.53 mL | 1.06 mL |
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产品说明书 for KY 02111
参考文献 for KY 02111
参考文献是支持产品生物活性的出版物。
Minami et al (2012) A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2 1448 PMID: 23103164
If you know of a relevant reference for KY 02111, please let us know.
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关键词: KY 02111, KY 02111 supplier, KY02111, stem, cell, differentiation, cardiomyocytes, human, iPSCs, ESCs, Wnt, signaling, pathway, inhibits, inhibitors, Other, Signaling, Cardiomyocyte, Stem, Cells, and, iPSC, 4731, Tocris Bioscience
2 篇 KY 02111 的引用文献
引用文献是使用了 Tocris 产品的出版物。 KY 02111 的部分引用包括：
Qui et al (2017) Rapamycin and CHIR99021 coordinate robust cardiomyocyte differentiation from human pluripotent stem cells via reducing p53-dependent apoptosis. J.Am.Heart Assoc. 6 e005295 PMID: 28971953
Chris et al (2020) Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour. F1000Res 8 1911 PMID: 32789000
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.