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Submit ReviewL-690,488
说明： Cell permeable prodrug of the IMPase inhibitor L-690,330 (Cat. No. 0681)
化学名： 1-[(4-Hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)]-2,2-dimethylpropanoate
纯度： ≥98% (HPLC)
生物活性 for L-690,488
L-690,488 is a cell-permeable prodrug of the potent inositol monophosphatase inhibitor L-690,330 (Cat. No. 0681); penetrates cells more effectively than its metabolite.
许可信息
Sold with the permission of Merck Sharp and Dohme Ltd.
技术数据 for L-690,488
| 分子量 | 754.7 |
| 公式 | C32H52O16P2 |
| 储存 | Store at -80°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 142523-14-6 |
| PubChem ID | 5132514 |
| InChI Key | LOTSPVPQHAUHCE-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(OC(P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)(C)P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for L-690,488
参考文献 for L-690,488
参考文献是支持产品生物活性的出版物。
Atack et al (1994) Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J.Pharmacol.Exp.Ther. 270 70 PMID: 8035344
Chen et al (1998) Stimulatory effect of Li on glucose transport in rat adipocytes is not mediated by elevation of IP1. Am.J.Physiol. 275 E272 PMID: 9688629
关键词: L-690,488, L-690,488 supplier, Inositol, monophosphatase, inhibitors, inhibits, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690488, 0682, Tocris Bioscience
1 篇 L-690,488 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-690,488 的部分引用包括：
Harding et al (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Mol Cancer 81 4261 PMID: 24002062
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