L-692,585

Discontinued Product

2261 has been discontinued.

View all Ghrelin Receptors products.
说明: Potent, non-peptide ghrelin receptor agonist
化学名: 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)

生物活性 for L-692,585

L-692,585 is a highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (Ki = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.

化合物库 for L-692,585

L-692,585 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for L-692,585

分子量 567.69
公式 C32H37N7O3
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 145455-35-2
PubChem ID 9872740
InChI Key AYBCFPXLXOLPIZ-JIPXPUAJSA-N
Smiles C[C@@H](O)CNC(C)(C)CC(=O)N[C@@H]1CCC2=CC=CC=C2N(CC2=CC=C(C=C2)C2=CC=CC=C2C2=NNN=N2)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for L-692,585

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参考文献 for L-692,585

参考文献是支持产品生物活性的出版物。

Jacks et al (1994) Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl GH secretagogue, on plasma GH, IGF-1, ACTH, cortisol, prolactin, Ins, and thyroxine levels in beagles. J.Endocrinol. 143 399 PMID: 7830002

Glavaski-Joksimovic et al (2002) Mechanism of action of the GH secretagogue, L-692,585, on isolated porcine somatotropes. J.Endocrinol. 175 625 PMID: 12475374

Smith et al (1999) Peptidomimetic regulation of GH secretion. Endocrine Rev. 18 621

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关键词: L-692,585, L-692,585 supplier, Potent, non-peptide, ghrelin, receptors, agonists, GHS-R1a, Receptors, Growth, Hormone, Secretagog, 1a, Ghrelin, L692585, 2261, Tocris Bioscience

1 篇 L-692,585 的引用文献

引用文献是使用了 Tocris 产品的出版物。 L-692,585 的部分引用包括:

Evron et al (2014) G Protein and β-arrestin signaling bias at the ghrelin receptor. J Biol Chem 289 33442 PMID: 25261469


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该领域的文献

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.