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Submit ReviewL-692,585 is a highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (Ki = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.
L-692,585 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
分子量 | 567.69 |
公式 | C32H37N7O3 |
储存 | Desiccate at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 145455-35-2 |
PubChem ID | 9872740 |
InChI Key | AYBCFPXLXOLPIZ-JIPXPUAJSA-N |
Smiles | C[C@@H](O)CNC(C)(C)CC(=O)N[C@@H]1CCC2=CC=CC=C2N(CC2=CC=C(C=C2)C2=CC=CC=C2C2=NNN=N2)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Jacks et al (1994) Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl GH secretagogue, on plasma GH, IGF-1, ACTH, cortisol, prolactin, Ins, and thyroxine levels in beagles. J.Endocrinol. 143 399 PMID: 7830002
Glavaski-Joksimovic et al (2002) Mechanism of action of the GH secretagogue, L-692,585, on isolated porcine somatotropes. J.Endocrinol. 175 625 PMID: 12475374
Smith et al (1999) Peptidomimetic regulation of GH secretion. Endocrine Rev. 18 621
关键词: L-692,585, L-692,585 supplier, Potent, non-peptide, ghrelin, receptors, agonists, GHS-R1a, Receptors, Growth, Hormone, Secretagog, 1a, Ghrelin, L692585, 2261, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 L-692,585 的部分引用包括:
Evron et al (2014) G Protein and β-arrestin signaling bias at the ghrelin receptor. J Biol Chem 289 33442 PMID: 25261469
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.