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Submit ReviewL-732,138
说明： Potent and selective NK1 antagonist
化学名： N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester
纯度： ≥98% (HPLC)
生物活性 for L-732,138
L-732,138 is a potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM).
许可信息
Sold with the permission of Merck Sharp and Dohme Ltd.
技术数据 for L-732,138
| 分子量 | 472.39 |
| 公式 | C22H18F6N2O3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 148451-96-1 |
| PubChem ID | 44396853 |
| InChI Key | BYYQYXVAWXAYQC-LJQANCHMSA-N |
| Smiles | O=C(N[C@@](CC2=CNC3=C2C=CC=C3)([H])C(OCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for L-732,138
参考文献 for L-732,138
参考文献是支持产品生物活性的出版物。
Cascieri et al (1994) Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. J.Biol.Chem. 269 6587 PMID: 7509807
Kuo et al (1998) Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways. Br.J.Pharmacol. 125 711 PMID: 9831906
MacLeod et al (1993) N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists. J.Med.Chem. 36 2044 PMID: 8393115
MacLeod et al (1994) Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor. J.Med.Chem. 37 1269 PMID: 7513763
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关键词: L-732,138, L-732,138 supplier, Potent, selective, NK1, antagonists, Tachykinin, Receptors, Neurokinin, L732138, merck, Receptor, 0868, Tocris Bioscience
2 篇 L-732,138 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-732,138 的部分引用包括：
Li et al (2013) Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells. J Neurosci 11 294 PMID: 23345604
Wan et al (2017) Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats. Front Mol Neurosci 9 167 PMID: 28119567
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