L-798,106

Cat. No. 3342 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and highly selective EP₃ antagonist

化学名： N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide

纯度： ≥99% (HPLC)

引用文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for L-798,106

L-798,106 is a potent and highly selective prostanoid EP₃ receptor antagonist (K_i values are 0.3, 916, > 5000 and > 5000 nM at EP₃, EP₄, EP₁ and EP₂ respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo.

化合物库 for L-798,106

L-798,106 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for L-798,106

分子量	536.44
公式	C₂₇H₂₂BrNO₄S
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	244101-02-8
PubChem ID	15551229
InChI Key	ODTKFNUPVBULRJ-NTCAYCPXSA-N
Smiles	O=C(NS(C4=C(OC)C=CC(Br)=C4)(=O)=O)/C=C/C1=CC=CC=C1CC3=CC2=CC=CC=C2C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for L-798,106

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	53.64	100

制备储备液 for L-798,106

以下数据基于产品分子量 536.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.32 mL	18.64 mL
5 mM	0.37 mL	1.86 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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产品说明书 for L-798,106

分析证书/产品说明书

化学品安全技术说明书

参考文献 for L-798,106

参考文献是支持产品生物活性的出版物。

Juteau et al (2001) Structure-activity relationships of cinnamic acylsulfonamide analogues on human EP₃ prostanoid receptor. Bioorg.Med.Chem. 9 1977 PMID: 11504634

Clarke et al (2004) E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP₃-subtype. Br.J.Pharmacol. 141 600 PMID: 14744812

Bassil et al (2008) Activation of prostaglandin EP receptors by lubipro. in rat and human stomach and colon. Br.J.Pharmacol. 154 126 PMID: 18332851

If you know of a relevant reference for L-798,106, please let us know.

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关键词: L-798,106, L-798,106 supplier, Potent, selective, EP3, antagonists, Receptors, Prostanoid, prostaglandins, prostacyclins, eicosanoids, L798106, 3342, Tocris Bioscience