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L-817,818

Cat. No. 1980 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective sst5 agonist
化学名： N2-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for L-817,818

L-817,818 is a potent and selective somatostatin sst5 receptor agonist. Ki values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5, sst1, sst2, sst3 and sst4 receptors respectively. Inhibits growth hormone release from rat pituitary cells (EC50 = 3.1 nM) and insulin release from mouse pancreatic islets (EC50 = 0.3 nM) in vitro.

化合物库 for L-817,818

L-817,818 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for L-817,818

分子量 536.67
公式 C33H36N4O3
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 217480-27-8
PubChem ID 9937014
InChI Key NFVRGDRCCNEGBS-KCWXNJEJSA-N
Smiles O=C(CC1=C(C4=CC=C(C=CC=C5)C5=C4)NC2=C1C=CC3=C2C=CC=C3)N[C@@H]([C@](OC[C@@H](N)C)=O)CCCCN

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for L-817,818

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 53.67 100

制备储备液 for L-817,818

以下数据基于产品分子量 536.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.32 mL 18.63 mL
5 mM 0.37 mL 1.86 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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产品说明书 for L-817,818

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for L-817,818

参考文献是支持产品生物活性的出版物。

Rohrer et al (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 282 737 PMID: 9784130

Rohrer and Schaeffer (2000) Identification and characterization of subtype selective somatostatin receptor agonists. J.Physiol.Paris 94 211 PMID: 11087999

Strowski et al (2000) Somatostatin inhibits Ins and glucagon secretion via two receptor subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Endocrinology 141 111 PMID: 10614629

If you know of a relevant reference for L-817,818, please let us know.

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关键词: L-817,818, L-817,818 supplier, Potent, selective, sst5, agonists, Receptors, Somatostatin, L817818, 1980, Tocris Bioscience

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