Lapatinib

Cat. No. 6811 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor

化学名： N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Lapatinib

Lapatinib is a potent and selective dual ErbB2 (HER-2) and EGFR inhibitor (IC₅₀ values are 9.8 and 10.2 nM, respectively). Selective for EGFR and ErbB-2 versus other proliferative kinases. Inhibits proliferation in multiple cancer cell lines (average IC₅₀ values <0.16 μM). Exhibits 100-fold average selectivity for the tumor cells versus human foreskin fibroblasts. Inhibits EGFR/ErbB2 autophosphorylation and phosphorylation of the downstream modulator AKT.

化合物库 for Lapatinib

Lapatinib is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Lapatinib

分子量	581.06
公式	C₂₉H₂₆ClFN₄O₄S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	231277-92-2
PubChem ID	208908
InChI Key	BCFGMOOMADDAQU-UHFFFAOYSA-N
Smiles	CS(=O)(CCNCC1=CC=C(C2=CC=C3N=CN=C(C3=C2)NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)O1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Lapatinib

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	58.11	100

制备储备液 for Lapatinib

以下数据基于产品分子量 581.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.72 mL	8.6 mL	17.21 mL
5 mM	0.34 mL	1.72 mL	3.44 mL
10 mM	0.17 mL	0.86 mL	1.72 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Lapatinib

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Lapatinib

参考文献是支持产品生物活性的出版物。

Rusnak et al (2001) The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol.Cancer Ther. 1 85 PMID: 12467226

If you know of a relevant reference for Lapatinib, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 EGFR Inhibitors

关键词: Lapatinib, Lapatinib supplier, Potent, selective, dual, ErbB2, (HER-2), and, EGFR, inhibitors, inhibits, 6811, Tocris Bioscience

1 篇 Lapatinib 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Lapatinib 的部分引用包括：

Gregory et al (2021) A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets. Sci Signal 14 PMID: 33727337

您是否知道使用了 Tocris Lapatinib 的优秀论文？请告知我们.

Lapatinib 的评论

目前没有该产品的评论。 Be the first to review Lapatinib and earn rewards!

Have you used Lapatinib?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.