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Lavendustin A

Cat. No. 1331 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1331 has been discontinued.

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说明： EGFR, p60c-src inhibitor
别名： RG 14355
化学名： 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid
纯度： ≥98% (HPLC)
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引用文献
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文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Lavendustin A

Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). Inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 μM).

技术数据 for Lavendustin A

分子量 381.38
公式 C21H19NO6
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 125697-92-9
PubChem ID 3894
InChI Key ULTTYPMRMMDONC-UHFFFAOYSA-N
Smiles OC1=CC=C(O)C=C1CN(CC3=C(O)C=CC=C3)C2=CC=C(O)C(C(O)=O)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Lavendustin A

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参考文献 for Lavendustin A

参考文献是支持产品生物活性的出版物。

Hsu et al (1991) Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue. J.Biol.Chem. 266 21105 PMID: 1939153

O'Dell et al (1991) Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353 558 PMID: 1656271

Onoda et al (1989) Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J.Nat.Prod. 52 1252 PMID: 2614420

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关键词: Lavendustin A, Lavendustin A supplier, EGFR, p60c-src, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, LavendustinA, RG14355, RG, 14355, Src, 1331, Tocris Bioscience

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