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Submit ReviewLDN 57444
说明： Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor
化学名： 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)
纯度： ≥98% (HPLC)
生物活性 for LDN 57444
LDN 57444 is an inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo.
技术数据 for LDN 57444
| 分子量 | 397.64 |
| 公式 | C17H11Cl3N2O3 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 668467-91-2 |
| PubChem ID | 24906255 |
| InChI Key | OPQRFPHLZZPCCH-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N(CC3=CC(Cl)=CC=C3Cl)C(C2=NOC(C)=O)=O)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LDN 57444
参考文献 for LDN 57444
参考文献是支持产品生物活性的出版物。
Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837 PMID: 14522054
Tan et al (2008) Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol.Cell.Biochem. 318 109 PMID: 18622688
Cartier et al (2009) Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J.Neurosci. 29 7857 PMID: 19535597
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关键词: LDN 57444, LDN 57444 supplier, LDN57444, UCH, L1, inhibitors, inhibits, ubiquitin, C-terminal, hydrolases, UCH-L1, Deubiquitinating, Enzymes, 3998, Tocris Bioscience
1 篇 LDN 57444 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LDN 57444 的部分引用包括：
Zlatic et al (2018) Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees. Cell Syst 6 368 PMID: 29397366
LDN 57444 的评论
平均评分: 4 (Based on 1 Review.)
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Culture with LDN57444.
By
Anonymous on 12/10/2019
分析类型： In Vitro
种属： Mouse
细胞系/组织： Fibroblasts
Basal oxygen consumption rates were collected for 4 hours following the addition of CuCl2, LDN57444
