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Submit ReviewLDV FITC
说明： Fluorescent ligand for α4β1 (VLA-4)
纯度： ≥90% (HPLC)
生物活性 for LDV FITC
LDV FITC is a fluorescent ligand that binds to the α4β1 integrin (VLA-4) with high affinity (Kd values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). Used to detect VLA-4 affinity and conformational changes. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.
技术数据 for LDV FITC
| 分子量 | 1368.54 |
| 公式 | C69H81N11O17S |
| 序列 | LDVPAAK (Modifications: Leu-1 N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-, Lys-6 N-FITC conjugate) |
| 储存 | Store at -20°C |
| 纯度 | ≥90% (HPLC) |
| CAS Number | 1207610-07-8 |
| PubChem ID | 91826076 |
| InChI Key | PAAUNHNWVWSJKI-CBRXRBRLSA-N |
| Smiles | CC(C)C[C@H](NC(=O)Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(C(O)=O)c(c1)-c1c-2ccc(=O)cc-2oc2cc(O)ccc12)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LDV FITC
| 溶解性 | Soluble to 1 mg/ml in PBS (pH 7.4) |
产品说明书 for LDV FITC
参考文献 for LDV FITC
参考文献是支持产品生物活性的出版物。
Chigaev et al (2001) Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn2+ or antibody activation. J.Biol.Chem. 276 48670 PMID: 11641394
Njus et al (2009) Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev.Technol. 7 507 PMID: 19754304
Chigaev et al (2003) FRET detection of cellular α4-integrin conformational activation. Biophys.J. 85 3951 PMID: 14645084
If you know of a relevant reference for LDV FITC, please let us know.
按标靶查看相关产品
- Fluorescent Probes and Stains
- Extracellular Matrix and Adhesion Molecules
- Cell Adhesion Molecules
- TR-FRET and FP Assay Reagents
- Cell Adhesion Molecule Peptides
- Fluorescent Receptor Probes
- Integrin Peptides
- Fluorescent Receptor Probe Peptides
- Fluorescent Integrin Probe Peptides
- TR-FRET and FP Assay Reagents Peptides
- Integrins
- Fluorescent Integrin Probes
- Fluorescence Imaging
关键词: LDV FITC, LDV FITC supplier, LDVFITC, VLA-4, very, late, antigen, VLA4, integrins, alpha4beta1, a4b1, α4, β1, fluorescent, ligands, TR-FRET, acceptor, Fluorescent, Receptor, Probes, Integrins, Cell, Adhesion, Molecules, Integrin, and, FP, Assay, Reagents, 4577, Tocris Bioscience
1 篇 LDV FITC 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LDV FITC 的部分引用包括：
Scott I et al (2013) On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction. Proc Natl Acad Sci U S A 110 13944-9 PMID: 23918401
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Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
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- Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
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