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Submit Review[Leu31,Pro34]-Neuropeptide Y (human, rat)
说明： NPY Y1 receptor agonist
别名： [Leu31,Pro34]-NPY (human)
纯度： ≥95% (HPLC)
生物活性
[Leu31,Pro34]-Neuropeptide Y (human, rat) is a high affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.
技术数据
| 分子量 | 4241 |
| 公式 | C189H284N54O56S |
| 序列 |
YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY (Modifications: Tyr-36 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 132699-73-1 |
| PubChem ID | 24868223 |
| InChI Key | MPWANDCMSKOYBR-MJWITIMHSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书
参考文献
参考文献是支持产品生物活性的出版物。
Bard et al (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J.Biol.Chem. 270 26762 PMID: 7592911
Fuhlendorff et al (1990) [Leu31, Pro34]Neuropeptide Y: a specific Y1 receptor agonist. Proc.Natl.Acad.Sci.U.S.A. 87 182 PMID: 2153286
Kask et al (1998) Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br.J.Pharmacol. 124 1507 PMID: 9723965
Michel et al (1998) XVI.International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143 PMID: 9549761
If you know of a relevant reference for [Leu31,Pro34]-Neuropeptide Y (human, rat), please let us know.
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关键词: [Leu31,Pro34]-Neuropeptide Y (human, rat), [Leu31,Pro34]-Neuropeptide Y (human, rat) supplier, NPY, Y1, receptor, agonists, Neuropeptide, Y, Receptors, [Leu31Pro34]-NeuropeptideY, (human,, rat), neuropeptides, [Leu31,Pro34]-NPY, (human), 1176, Tocris Bioscience
3 篇 [Leu31,Pro34]-Neuropeptide Y (human, rat) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 [Leu31,Pro34]-Neuropeptide Y (human, rat) 的部分引用包括：
Yu et al (2016) Neuropeptide Y1 Receptor Regulates Glucocorticoid-Induced Inhibition of Osteoblast Differentiation in Murine MC3T3-E1 Cells via ERK Signaling. Int J Mol Sci 17 PMID: 28009825
Maymon et al (2019) Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD. Neuropharmacology 162 PMID: 31622603
Malet (2017) Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury. Peptides 92 38 PMID: 28465077
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[Leu31,Pro34]-Neuropeptide Y current in spinal dorsal horn neuron.
By
Allen Dickie on 03/24/2023
分析类型： Ex Vivo
种属： Mouse
Whole cell patch clamp recording (voltage clamp) from spinal dorsal horn interneuron, in ex vivo slice preparation, in response to bath application of [Leu31,Pro34]-Neuropeptide Y (300 nM), in the presence of TTX, bicuculline and strychnine.
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