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Leukadherin 1

Cat. No. 4921 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4921 has been discontinued.

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说明： Allosteric activator of CD11b/CD18
化学名： 4-[(5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid
纯度： ≥98% (HPLC)
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引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for Leukadherin 1

Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.

技术数据 for Leukadherin 1

分子量 421.49
公式 C22H15NO4S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 344897-95-6
PubChem ID 5342077
InChI Key AEZGRQSLKVNPCI-UNOMPAQXSA-N
Smiles S=C(N(CC3=CC=CC=C3)C2=O)S/C2=C\C1=CC=C(C4=CC=C(C(O)=O)C=C4)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Leukadherin 1

参考文献是支持产品生物活性的出版物。

Maiguel et al (2011) Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci.Signal. 4 1 PMID: 21900205

Reed et al (2013) Complement receptor 3 influences Toll-like receptor 7/8-dependent inflammation. J.Biol.Chem. 288 9077 PMID: 23386618

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关键词: Leukadherin 1, Leukadherin 1 supplier, anti-inflammatory, anti-inflammatories, inflammation, leukocyte, extravasation, trans-endothelial, migration, adhesion, CD11b/CD18, activators, allosteric, integrins, Integrins, Cell, Adhesion, Molecules, 4921, Tocris Bioscience

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