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Submit ReviewLevcromakalim
说明： Kir6 (KATP) channel opener; active enantiomer of Cromakalim
别名： BRL 38227
化学名： (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
纯度： ≥99% (HPLC)
生物活性 for Levcromakalim
Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener Cromakalim. Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.
许可信息
Sold under license
技术数据 for Levcromakalim
| 分子量 | 286.33 |
| 公式 | C16H18N2O3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 94535-50-9 |
| PubChem ID | 93504 |
| InChI Key | TVZCRIROJQEVOT-CABCVRRESA-N |
| Smiles | O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Levcromakalim
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 2.86 | 10 |
制备储备液 for Levcromakalim
以下数据基于产品分子量 286.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.92 mL | 174.62 mL | 349.25 mL |
| 0.5 mM | 6.98 mL | 34.92 mL | 69.85 mL |
| 1 mM | 3.49 mL | 17.46 mL | 34.92 mL |
| 5 mM | 0.7 mL | 3.49 mL | 6.98 mL |
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产品说明书 for Levcromakalim
参考文献 for Levcromakalim
参考文献是支持产品生物活性的出版物。
Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919 PMID: 2002472
Noack et al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945 PMID: 1467843
Taylor et al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429 PMID: 1578358
If you know of a relevant reference for Levcromakalim, please let us know.
关键词: Levcromakalim, Levcromakalim supplier, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, BRL38227, BRL, 38227, rectifier, 1378, Tocris Bioscience
3 篇 Levcromakalim 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Levcromakalim 的部分引用包括：
Fike et al (2013) Reactive oxygen species scavengers improve voltage-gated K(+) channel function in pulmonary arteries of newborn pigs with progressive hypoxia-induced pulmonary hypertension. Pulm Circ 3 551 PMID: 24618540
Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Lab Chip 10 e0121634 PMID: 25803863
Garland et al (2015) TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery. Br J Pharmacol 172 1114 PMID: 25323322
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Levcromakalim 的评论
平均评分: 5 (Based on 1 Review.)
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Levcromakalim was used on BK channel opening properties compared to cromakalim.
By
Anonymous on 11/28/2018
分析类型： In Vitro
种属： Human
Levcromakalim was used on our lab to understand its BK channel opening properties compared to cromakalim. Results were reproducible.
