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Submit ReviewLoratidine
Discontinued Product
1944 has been discontinued.
View all Histamine H<sub>1</sub> Receptors products.
说明： Peripheral H1 antagonist; antiallergic agent
别名： SCH 29851
化学名： 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
纯度： ≥99% (HPLC)
生物活性 for Loratidine
Loratidine is a peripheral histamine H1 receptor antagonist (Ki = 35 nM); devoid of central effects. Orally active antiallergic agent.
化合物库 for Loratidine
Loratidine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Loratidine
| 分子量 | 382.88 |
| 公式 | C22H23ClN2O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 79794-75-5 |
| PubChem ID | 3957 |
| InChI Key | JCCNYMKQOSZNPW-UHFFFAOYSA-N |
| Smiles | CCOC(=O)N1CC\C(CC1)=C1/C2=NC=CC=C2CCC2=C1C=CC(Cl)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Loratidine
化学品安全技术说明书目前不在网上提供。
请联系客户服务。
请联系客户服务。
参考文献 for Loratidine
参考文献是支持产品生物活性的出版物。
Ahn and Barnett (1986) Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. Eur.J.Pharmacol. 127 153 PMID: 2875889
Barnett et al (1984) Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents Actions 14 590 PMID: 6236679
Kreutner et al (1987) Antiallergic activity of loratidine, a non-sedating antihistamine. Allergy 42 57 PMID: 2436504
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关键词: Loratidine, Loratidine supplier, Peripheral, H1, antagonists, anti-allergic, agent, Receptors, Histamine, histaminergic, SCH29851, SCH, 29851, 1944, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.