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LW 6

Cat. No. 6322 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
别名： CAY 10585
化学名： Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]benzoate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LW 6

LW 6 is a malate dehydrogenase-2 (MDH2) inhibitor (IC50 = 6.3 μM). Also inhibits HIF-1α. Prevents accumulation of HIF-1α in Hep3B cells under hypoxic conditions (IC50 = 2.6 μM) with resulting decrease in expression of HIF-1α target genes VEGF and EPO. Inhibits proliferation of activated human T cells ex vivo.

化合物库 for LW 6

LW 6 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for LW 6

分子量 435.51
公式 C26H29NO5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 934593-90-5
PubChem ID 16124726
InChI Key BJRPPNOJYFZSLY-QXRPDJHGSA-N
Smiles O=C(C1=CC=C(C(NC(COC2=CC=C(C3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3)C=C2)=O)=C1)O)OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LW 6

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 21.78 50

制备储备液 for LW 6

以下数据基于产品分子量 435.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.59 mL 22.96 mL 45.92 mL
2.5 mM 0.92 mL 4.59 mL 9.18 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
25 mM 0.09 mL 0.46 mL 0.92 mL

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参考文献 for LW 6

参考文献是支持产品生物活性的出版物。

Eleftheriadis et al (2015) Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells. Exp.Ther.Med. 5 1959 PMID: 26640580

Lee et al (2007) (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. J.Med.Chem. 50 1675 PMID: 17328532

Ban et al (2016) A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration. PLoS One 9 e0162568 PMID: 27611801

If you know of a relevant reference for LW 6, please let us know.

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关键词: LW 6, LW 6 supplier, LW6, Malate, dehydrogenase-2, MDH2, inhibitor, inhibitors, inhibits, HIF-1alfa, HIF-1alpha, HIF-1a, hypoxia, inducible, factor, CAY10585, CAY, 10585, Other, Dehydrogenases, Hypoxia, Inducible, Factors, 6322, Tocris Bioscience

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