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LY 255283

Cat. No. 2208 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective, competitive BLT2 receptor antagonist
化学名： 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LY 255283

LY 255283 is a selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration..

化合物库 for LY 255283

LY 255283 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LY 255283

分子量 360.46
公式 C19H28N4O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 117690-79-6
PubChem ID 122023
InChI Key WCGXJPFHTHQNJL-UHFFFAOYSA-N
Smiles CCC1=C(OCCCCCC(C)(C)C2=NN=NN2)C=C(O)C(=C1)C(C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LY 255283

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.05 100
ethanol 9.01 25

制备储备液 for LY 255283

以下数据基于产品分子量 360.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.74 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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产品说明书 for LY 255283

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for LY 255283

参考文献是支持产品生物活性的出版物。

Herron et al (1992) Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. J.Med.Chem. 35 1818 PMID: 1316967

Silbaugh et al (1992) Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. Eur.J.Pharmacol. 223 57 PMID: 1335877

Yokomizo et al (2001) Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J.Biol.Chem. 276 12454 PMID: 11278893

If you know of a relevant reference for LY 255283, please let us know.

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关键词: LY 255283, LY 255283 supplier, Selective, competitive, BLT2, receptor, antagonists, CysLT1, Receptors, CysLT2, BLT1, OXE, Oxoeicosanoid, receptors, LTD4, LTE4, leukotrienes, eicosanoids, LY255283, Leukotriene, and, Related, 2208, Tocris Bioscience

1 篇 LY 255283 的引用文献

引用文献是使用了 Tocris 产品的出版物。 LY 255283 的部分引用包括：

Cabral et al (2015) Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. PLoS One 3 PMID: 26216432

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