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Submit ReviewLY 266097 hydrochloride
说明： Selective 5-HT2B antagonist
化学名： 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
纯度： ≥99% (HPLC)
生物活性 for LY 266097 hydrochloride
LY 266097 hydrochloride is a selective 5-HT2B receptor antagonist (pKi = 9.3). More than 100-fold selective over 5-HT2A and 5-HT2C. Attenuates amphetamine-induced locomotion in the rat.
化合物库 for LY 266097 hydrochloride
LY 266097 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for LY 266097 hydrochloride
| 分子量 | 407.33 |
| 公式 | C21H23ClN2O2.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 172895-39-5 |
| PubChem ID | 9953184 |
| InChI Key | KPXKZZURYAXZQE-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4Cl)C2=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LY 266097 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 40.73 | 100 | |
| ethanol | 40.73 | 100 |
制备储备液 for LY 266097 hydrochloride
以下数据基于产品分子量 407.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.28 mL | 24.55 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.91 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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产品说明书 for LY 266097 hydrochloride
参考文献 for LY 266097 hydrochloride
参考文献是支持产品生物活性的出版物。
Audia et al (1996) Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5-HT2B) contractile receptor in the rat stomach fundus. J.Med.Chem. 39 2773 PMID: 8709108
Auclair et al (2010) The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens DArgic pathway activity. J.Neurochem. 114 1323 PMID: 20534001
If you know of a relevant reference for LY 266097 hydrochloride, please let us know.
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关键词: LY 266097 hydrochloride, LY 266097 hydrochloride supplier, LY266097, HCl, 5HT2B, 5ht-2b, receptor, antagonists, 5-ht2b, antagonist, serotonin, serotonergic, 2B, receptors, 5-HT2B, Receptors, 4081, Tocris Bioscience
1 篇 LY 266097 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LY 266097 hydrochloride 的部分引用包括：
McCorvy et al (2018) Structural determinants of 5-HT2B receptor activation and biased agonism. Nat Struct Mol Biol 25 787 PMID: 30127358
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.