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LY 272015 hydrochloride

Cat. No. 3077 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity 5-HT2B antagonist; orally active
化学名： 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LY 272015 hydrochloride

LY 272015 hydrochloride is a high affinity 5-HT2B receptor antagonist that displays selectivity over 5-HT2A and 5-HT2C receptors (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Orally active.

许可信息

Sold under license from Eli Lilly and company

化合物库 for LY 272015 hydrochloride

LY 272015 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LY 272015 hydrochloride

分子量 372.89
公式 C21H24N2O2.HCl
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 172895-15-7
PubChem ID 9929423
InChI Key BKAZOTIBKRWLQA-UHFFFAOYSA-N
Smiles CC1=CC=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4)C2=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LY 272015 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.29 100
ethanol 3.73 10

制备储备液 for LY 272015 hydrochloride

以下数据基于产品分子量 372.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.41 mL 26.82 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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产品说明书 for LY 272015 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for LY 272015 hydrochloride

参考文献是支持产品生物活性的出版物。

Sevoz-Couche et al (2000) In vivo modulation of vagal-identified dorsal medullary neurones by activation of different 5-Hydroxytryptamine2 receptors in rat. Br.J.Pharmacol. 131 1445 PMID: 11090119

Cohen et al (1996) LY272015, a potent, selective and orally active 5-HT2B receptor antagonist. J.Serotonin Res. 3 131

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395 PMID: 21789169

If you know of a relevant reference for LY 272015 hydrochloride, please let us know.

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关键词: LY 272015 hydrochloride, LY 272015 hydrochloride supplier, High, affinity, 5-HT2B, antagonists, orally, active, Serotonin, Receptors, LY272015, hydrochloride, 3077, Tocris Bioscience

3 篇 LY 272015 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 LY 272015 hydrochloride 的部分引用包括：

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. PLoS One 3 e00103 PMID: 25692021

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. J Pharmacol Exp Ther 6 e21395 PMID: 21789169

Soll et al (2012) Expression of serotonin receptors in human hepatocellular cancer. Clin Cancer Res 18 5902 PMID: 23087410

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LY 272015 hydrochloride 的评论

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5-HT has a potential for relaxant.
By Anonymous on 02/18/2020
分析类型： In Vivo
种属： Rat

LY272015 (1 lmol/L)

PMID: 25692021
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